Nanotechnology approaches the shipbuilding industry

Recently, from the National Institute of Materials Science of the Institute of Metal Research of the Chinese Academy of Sciences, the news has reached a breakthrough in the research of nanomaterials in China: a piece of pure iron with a palm of the hand is subjected to surface nano-treatment and then subjected to nitriding treatment. The 10 micron thick nitride layer requires a temperature drop of more than 200 degrees and a processing time of 9 hours.

It is reported that the research results have solved the technical bottleneck in the surface nitriding of metal materials for a long time, showing that the advanced technology of nanometer is expected to be applied to traditional industries such as shipbuilding, and plays an important role in upgrading its technology.

Rucaparib is an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types.

Rucaparib Intermediates

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 Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com

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